Chenodiol
Chenodiol (chenodiol) is a small molecule pharmaceutical. Chenodiol was first approved as Chenix on 1983-07-28. The pharmaceutical is active against bile acid receptor. In addition, it is known to target fMet-Leu-Phe receptor and G-protein coupled bile acid receptor 1.
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Clinical Trials
38 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | 3 | 1 | 6 |
| Malabsorption syndromes | D008286 | EFO_0009554 | K90 | — | 1 | — | 2 | — | 3 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | 3 | — | 3 |
| Gallstones | D042882 | EFO_0004210 | — | — | 1 | — | 1 | — | 2 |
| Cholelithiasis | D002769 | EFO_0004799 | K80 | — | 1 | — | 1 | — | 2 |
| Cholecystolithiasis | D041761 | EFO_1000864 | — | — | 1 | — | 1 | — | 2 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Biliary liver cirrhosis | D008105 | — | K74.3 | 1 | 4 | 1 | — | 2 | 8 |
| Cerebrotendinous xanthomatosis | D019294 | — | — | 1 | 1 | 2 | — | 2 | 6 |
| Xanthomatosis | D014973 | HP_0001114 | — | 1 | 1 | 2 | — | 2 | 6 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 3 | 2 | — | — | 5 |
| Fibrosis | D005355 | — | — | — | 3 | 2 | — | — | 5 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 1 | 1 | — | — | 2 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 1 | 1 | — | — | 1 | 3 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | 1 | — | — | 2 | 3 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | 1 | — | — | — | 2 |
| Lipodystrophy | D008060 | HP_0009125 | E88.1 | — | 1 | — | — | — | 1 |
| Familial partial lipodystrophy | D052496 | — | — | — | 1 | — | — | — | 1 |
| Muscle spasticity | D009128 | HP_0001257 | — | — | 1 | — | — | — | 1 |
| Hereditary spastic paraplegia | D015419 | EFO_0000529 | G11.4 | — | 1 | — | — | — | 1 |
| Paraplegia | D010264 | HP_0001258 | G82.2 | — | 1 | — | — | — | 1 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | — | — | — | 1 |
| Constipation | D003248 | HP_0002019 | K59.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 1 | 3 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Echolocation | D004455 | — | — | 1 | — | — | — | — | 1 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | 1 | — | — | — | — | 1 |
| Hyperlipoproteinemia type iv | D006953 | Orphanet_413 | E78.1 | 1 | — | — | — | — | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | 1 | — | — | — | — | 1 |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | 1 | — | — | — | — | 1 |
| Familial combined hyperlipidemia | D006950 | EFO_0000492 | E78.49 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dermatitis | D003872 | HP_0011123 | L30.9 | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Peroxisomal disorders | D018901 | Orphanet_44 | E71.5 | — | — | — | — | 1 | 1 |
| Zellweger syndrome | D015211 | Orphanet_912 | E71.510 | — | — | — | — | 1 | 1 |
| Infantile refsum disease | D052919 | Orphanet_772 | G60.1 | — | — | — | — | 1 | 1 |
| Adrenoleukodystrophy | D000326 | Orphanet_43 | E71.52 | — | — | — | — | 1 | 1 |
| Refsum disease | D012035 | Orphanet_773 | G60.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chenodiol |
| INN | chenodeoxycholic acid |
| Description | Chenodeoxycholic acid is a dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of a chenodeoxycholate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O |
Identifiers
| PDB | — |
| CAS-ID | 474-25-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL240597 |
| ChEBI ID | 16755 |
| PubChem CID | 10133 |
| DrugBank | DB06777 |
| UNII ID | 0GEI24LG0J (ChemIDplus, GSRS) |
Target
Agency Approved
NR1H4
NR1H4
Organism
Homo sapiens
Gene name
NR1H4
Gene synonyms
BAR, FXR, HRR1, RIP14
NCBI Gene ID
Protein name
bile acid receptor
Protein synonyms
farnesoid X nuclear receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Uniprot ID
Mouse ortholog
Nr1h4 (20186)
bile acid receptor (Q60641)
Variants
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Trends
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Safety
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Adverse Events
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321 adverse events reported
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